Hybridoma Yli-90, Producing Mabs Specific For Mouse Ly49i

Abstract

This invention concerns a hybridoma producing a mouse IgG1/kappa monoclonal antibody specific for the mouse Ly49I receptor. Mouse Ly49I is a homodimeric protein expressed on the surface of a large fraction (approximately 40%) of NK cells, and a small fraction of T cells. The receptor binds to classical class I molecules in most strains tested, including the Kbeta molecule. Ligand binding inhibits NK cell functions such as cytotoxicity.

Applications

The antibody is useful for staining the T cells and/or the NK cells that express the mouse 4Ly49I receptor.
The antibody may block ligand binding.